Method performance was evaluated for evaporative effects, assay recovery, ion suppression and phospholipid removal.
MSACL 2016 Tags: 96-well plate, Acidic, Clinical, English, LC-MS/MS, MMA (Methylmalonic acid), Methylmalonic acid (MMA), Posters, Serum The ISOLUTE® family of anion exchange sorbents are used to extract organic anions (acid compounds capable of exhibiting a negative charge) from both aqueous and non-aqueous matrixes.
The alto saxophones have upper and lower stack adjusting screws for exacting final adjustments.
This application note describes a simple, effective protocol for the extraction of methylmalonic acid (MMA) from serum using ISOLUTE® SAX strong anion exchange solid phase extraction plates, demonstrating high, reproducible analyte recoveries with low protein and phospholipid content in the extracts.
ISOLUTE SAX is supplied with a chloride counter ion.
ISOLUTE SAX is available in a wide range of SPE columns and 96-well plate formats.
Tags: Application Notes, Clordane, Column, Dicofol, Endosulfan, Food, Food, GC-MS, Organochlorines, Organophosphate Pesticide, Organophosphates, Pesticides, Vegetables The following method describes the extraction and separation of non-conjugated parent, glucuronide conjugates and sulfate conjugates of a proprietary pharmaceutical from urine and bile using non-polar and anion exchange mechanisms.Very clean extracts are possible due to the purely anion exchange retention mechanism available using this silica based sorbent.This minimizes the co-extraction of endogenous interferences through hydrophobic (or non-polar) retention.This technical note describes their use for aqueous matrices only.Although extraction using these sorbents is by the same mechanism, each has properties which influence the way they are used.
Tags: Manuals & User Guides This poster summarizes various sample preparation strategies for the extraction of MMA from serum without the necessity for derivatization, prior to LC-MS/MS analysis.